4/15/2023 0 Comments Isiplot 1 3 keygen generatorIn this experiment, we examined the functional specificity of neurons in the β -nucleus of the IO of rabbits by recording their activity during natural vestibular and optokinetic stimulation. In particular, the IO receives a GABAergic input that is most densely concentrated in the β -nucleus. The inferior olive (IO) appears to be organized functionally in discrete subnuclei that receive transmitter-specific inputs. Based on modeling of the experimental data, we propose that feed-forward inhibition, by controlling the fine scale patterns of Purkinje cell activity, enables the induction of plasticity in neurons of the cerebellar and vestibular nuclei. Purkinje cells showed abnormal patterns of simple spikes, both during and in the absence of evoked compensatory eye movements. Whereas impairment of baseline motor performance was relatively mild, the ability to adapt the phase of the vestibulo-ocular reflex and to consolidate gain adaptations, was strongly compromised. Using a mouse line (PC-Δγ2) in which GABAA receptor-mediated synaptic inhibition was selectively removed from Purkinje cells, we examined how feed-forward inhibition from molecular layer interneurons regulates adaptation of the vestibulo-ocular reflex. Although feed-forward inhibition onto Purkinje cells was first documented forty years ago, we still understand little of how inhibitory interneurons contribute to cerebellar function in behaving animals.
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